Mouse Monoclonal Antibody to SMC1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human;
Clone: 5B6;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human SMC1 expressed in E. Coli. ;
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 143kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=392
Reference: 1. Cell Cycle. 2006 Nov 1;5(21):2537-42. ; 2. FEBS Lett. 2007 Jun 26;581(16):3005-12.

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