Mouse Monoclonal Antibody to UBE1L

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting.Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5B10;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human UBE1L expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 112kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=494
Reference: 1. Cancer Res. 1992 Mar 15;52(6):1536-41 ; 2. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6071-5. ; 3. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3806-11.

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