Mouse Monoclonal Antibody to ABCG2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse; Monkey
Clone: 1H2;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ABCG2 expressed in E. Coli. ;
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 72kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=618
Reference: 1. Carcinogenesis. 2008 Dec;29(12):2289-97. ; 2. Pharm Res. 2009 Feb;26(2):449-58.

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