Mouse Monoclonal Antibody to KIT

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and, more specifically, is closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene (v-Kit), encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis, cell prolif- eration, apoptosis and adhesion. c-Kit is also identical with the product of the W locus in mice and, as such, is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and is encoded at the murine steel (SI) locus. Kit is the human homolog of the proto- oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1C5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human KIT expressed in E. Coli. ;
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 145kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=658
Reference: 1. Curr Hematol Malig Rep. 2009 Apr;4(2):77-82. ; 2. Georgian Med News. 2010 Mar;(180):13-9. ;

Note: Highly recommend to send quote request for product availability and estimated shipping charge