Figure 1: Western blot analysis using FLT3 mAb against human FLT3 recombinant protein. (Expected MW is 32.6 kDa)

Mouse Monoclonal Antibody to FLT3

30507

Regular price $341.00 You Pay

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7B7C3;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human FLT3 (AA: 930-991) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 130kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3468
Reference: 1. J Immunol. 2012 Oct 15;189(8):3822-30. ; 2. Cancer. 2012 Dec 15;118(24):6110-7. ;

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