Mouse Monoclonal Antibody to MMP2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse
Clone: 2B11E6;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human MMP2 (AA: 9-140) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 23.4kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4276
Reference: 1.Reprod Biol Endocrinol. 2015 Sep 4;13:102. ; 2.PLoS One. 2015 Mar 27;10(3):e0121404. ;

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