GeneAbTM BRAF V600E [IHC600] on Thyroid Gland

Anti-BRAF V600E Monoclonal Antibody

IHC600-100

$210.00 You Pay

Supplier: GenomeMe

Description:

Serine/threonine-protein kinase B-Raf (BRAF) is a cytoplasmic serine-threonine kinase of the RAF family which mediates downstream cellular responses to growth signals through the mitogen-activated protein kinase (MAPK) signaling pathway. Oncogenic mutations in the BRAF gene, 80% of which are a single V600E substitution within the kinase domain, constitutively activate the MAPK signaling pathway and result in increased cell proliferation and apoptosis resistance. The V600E mutation is observed in colorectal cancer, non-Hodgkin lymphoma, papillary thyroid carcinoma, malignant melanoma, non-small-cell lung carcinoma, and lung adenocarcinoma. BRAF V600E is therefore an important immunohistochemical marker for tumor diagnosis and prognosis.

Specifications:

Clone IHC600
Source Mouse Monoclonal
Positive Control

Colorectal Adenocarcinoma, Thyroid Papillary Carcinoma with the BRAF V600E Mutation
Dilution Range 1:100 - 1:400

IFU & SDS:

References

  1. Li WQ, et al. Mol Cancer. 2006; 5:2
  2. Davies H, et al. Nature. 2002; 417:949-954.
  3. Benlloch S, et al. J Mol Diagn. 2006; 8: 540–3.
  4. Gear H, et al. Invest Ophthalmol Vis Sci. 2006; 45:2484–8.
  5. Capper D, et al. Acta Neuropathol. 2011; 122:11-19.