Recombinant Mouse Herpesvirus Entry Mediator Protein

Supplier: Elabscience Product Name: Recombinant Mouse Herpesvirus Entry Mediator Protein Catalog No. PKSM040955 Product Type: recombinant protein Size: 50 ug Activity: Measured by its binding ability in a functional ELISA.Immobilized mouse HVEM-Fcat 10 ?g/mL (100 ?l/well) can bind biotinylated mouse BTLA-Fc ?The EC50 of biotinylated mouse BTLA-Fc is 152-228 ng/mL. Protein Construction: Recombinant Mouse Herpesvirus Entry Mediator is produced by our Mammalian expression system and the target gene encoding Gln39-Val207 is expressed with a Fc tag at the C-terminus. Sequence: Met 1-Gln 206 Fusion Tag: C-Fc Accession: NP_849262.1 Species: Mouse Expressed Host: Human Cells Shipping Conditions: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 45.6 kDa Applied MM: 50&60kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Reconstitution: Please refer to it for detailed information. Background: Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. It has demonstrated that HVEM Ig is able to exert a significant antiviral effect against HSV-1 infection in vivo.