Mouse Monoclonal Antibody to ACLY

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. ; ; ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/50; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse; Monkey; Rat
Clone: 5F8D11;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ACLY (AA: 306-502 ) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 125kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=836
Reference: 1.J Biol Chem. 2010 Oct 15;285(42):32606-15. ; 2.Int J Cancer. 2010 May 15;126(10):2282-95. ;

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