Mouse Monoclonal Antibody to ATRX

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: N/A; IHC: N/A
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 8B2H9
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ATRX (AA: 2311-2492) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 282.5kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4383
Reference: 1.Nat Commun. 2015 Jul 6;6:7538. 2.Oncotarget. 2015 Jul 20;6(20):18105-15.

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