Recombinant Mouse Transforming Growth Factor ?-1/TGF?1/TGFB1 Protein

Supplier: Elabscience Product Name: Recombinant Mouse Transforming Growth Factor ?-1/TGF?1/TGFB1 Protein Catalog No. PKSM041167 Product Type: recombinant protein Size: 50 ug Activity: Measured by its ability to inhibit IL-4-dependent proliferation of TF?1 human erythroleukemic cells.The ED50 for this effect is less than 1 ng/ml. Protein Construction: Recombinant Mouse Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed. Sequence: Ala279-Ser390 Fusion Tag: Accession: P04202 Species: Mouse Expressed Host: Human Cells Shipping Conditions: The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 12.8 kDa Applied MM: 14 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of 50mM Glycine,150mM NaCl,pH 2.5. Reconstitution: Please refer to the printed manual for detailed information. Background: Transforming growth factor beta 1 (TGF?1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-?1, TGF-?2 and TGF-?3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-? receptor type II (T?R-II), and a TGF-? receptor type I (T?R-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-? expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.