Recombinant Mouse Transforming Growth Factor-? Receptor Type II/TGFBR2 Protein(C-Fc)

Supplier: Elabscience Product Name: Recombinant Mouse Transforming Growth Factor-? Receptor Type II/TGFBR2 Protein(C-Fc) Catalog No. PKSM041170 Product Type: recombinant protein Size: 50 ug Activity: Protein Construction: Recombinant Mouse Transforming Growth Factor-beta Receptor Type II is produced by our Mammalian expression system and the target gene encoding Ile24-Asp159 is expressed with a Fc tag at the C-terminus. Sequence: Ile24-Asp159 Fusion Tag: C-Fc Accession: Q62312-2 Species: Mouse Expressed Host: Human Cells Shipping Conditions: The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 42.3 kDa Applied MM: 55-65 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH7.4. Reconstitution: Please refer to the printed manual for detailed information. Background: Transforming growth factor-? (TGF-?) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-? regulates cellular processes by binding to three high-affinity cell surface receptors: TGF-? receptor type I (TGF-?-RI), TGF-? receptor type II (TGF-?-RII), and TGF-?? receptor type III (TGF-?-RIII). TGF-? RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-?) receptor subfamily. TGF-? RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.