Recombinant Mouse Tyrosine-Protein Kinase Receptor TYRO3/DTK Protein(C-Fc)

Supplier: Elabscience Product Name: Recombinant Mouse Tyrosine-Protein Kinase Receptor TYRO3/DTK Protein(C-Fc) Catalog No. PKSM041178 Product Type: recombinant protein Size: 50 ug Activity: Protein Construction: Recombinant Mouse Developmental Tyrosine Kinase/Tyrosine Protein Kinase Receptor TYRO3 is produced by our Mammalian expression system and the target gene encoding Ala31-Ser418 is expressed with a Fc tag at the C-terminus. Sequence: Ala31-Ser418 Fusion Tag: C-Fc Accession: P55144 Species: Mouse Expressed Host: Human Cells Shipping Conditions: The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 68.9 kDa Applied MM: 90-120 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH 7.4. Reconstitution: Please refer to the printed manual for detailed information. Background: Dtk, also called Tyro3, belongs to the TAM receptor family of receptor protein tyrosine kinases (RPTKs) composed of three receptors Tyro3, Axl, and Mer. These receptors share a characteristic molecular structure of two immunoglobulin-like and two fibronectin type III repeats and have been best characterized for their roles in immune regulation, fertility, thrombosis and phagocytosis. Gas6 and protein S have been identified as ligands for these receptors. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Tyro3 and Axl play important regulatory roles in a variety of tissues, including the central nervous, reproductive, immune, and vascular systems. Tyro3 is widely expressed during embryonic development and preferentially expressed during neurogenesis in the central nervous system.