Recombinant Mouse Discoidin domain-containing receptor 2 Protein

Supplier: Elabscience Product Name: Recombinant Mouse Discoidin domain-containing receptor 2 Protein Catalog No. PKSM041190 Product Type: recombinant protein Size: 50 ug Activity: The specific activity was determined to be 2 nmol/min/mg using synthetic modified AXLtide peptide (modified-CKKSRGDYMTMQIG) as substrate. Protein Construction: Recombinant Mouse Discoidin domain-containing receptor 2 is produced by our Mammalian expression system and the target gene encoding Gln24-Arg399 is expressed with a 6His tag at the C-terminus. Sequence: Leu444-Val874 Fusion Tag: C-6His Accession: Q03146-2 Species: Mouse Expressed Host: Human Cells Shipping Conditions: Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.Shipment made at ambient temperature may seriously affect the activity of the ordered products. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 43.5 kDa Applied MM: 60-75 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH7.4. Reconstitution: Please refer to it for detailed information. Background: Discoidin domain receptor-2 (DDR2) is a cell surface tyrosine kinase receptor that can be activated by soluble collagen and has been implicated in diverse physiological functions including organism growth and wound repair. DDR2 binds to and is activated by collagen I, II, III, V, and X, with the notable exception of basement membrane collagen IV. DDR2 is expressed in connective tissues arising from embryonic mesoderm. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling.