Recombinant Mouse T-lymphocyte Activation Antigen CD80 Protein
PKSM041219
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Supplier: Elabscience
Product Name: Recombinant Mouse T-lymphocyte Activation Antigen CD80 Protein
Catalog No. PKSM041219
Product Type: recombinant protein
Size: 50 ug
Activity: Measured by its ability to bind recombinant mouse CD28 in a functional ELISA.
Protein Construction: Recombinant Mouse T-lymphocyte Activation Antigen CD80 is produced by our Mammalian expression system and the target gene encoding Val38-Asn246 is expressed with a 6His tag at the C-terminus.
Sequence: Val38-Asn246
Fusion Tag: C-6His
Accession: Q00609
Species: Mouse
Expressed Host: Human Cells
Shipping Conditions: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Purity: ?95% as determined by reducing SDS-PAGE.
Endotoxin: <1.0 EU per ?g as determined by LAL test.
Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7? for 2-7 days.
Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 24.6 kDa Applied MM: 38-55 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH7.4. Reconstitution: Please refer to it for detailed information. Background: Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. Mouse CD80 consists of an extracellular domain (ECD) with twoimmunoglobulin-like domains, transmembrane segment, and cytoplasmic domain. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.
Reconstituted protein solution can be stored at 4-7? for 2-7 days.
Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 24.6 kDa Applied MM: 38-55 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH7.4. Reconstitution: Please refer to it for detailed information. Background: Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. Mouse CD80 consists of an extracellular domain (ECD) with twoimmunoglobulin-like domains, transmembrane segment, and cytoplasmic domain. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.
