Recombinant Mouse SLAM Family Member 2 Protein

Supplier: Elabscience Product Name: Recombinant Mouse SLAM Family Member 2 Protein Catalog No. PKSM041220 Product Type: recombinant protein Size: 50 ug Activity: 1. Measured by its ability to bind human 2B4 in a functional ELISA.2. Measured by its ability to bind biotinylated recombinant mouse CD2 in a functional ELISA. Protein Construction: Recombinant Mouse SLAM Family Member 2 is produced by our Mammalian expression system and the target gene encoding Phe23-Arg216 is expressed with a 6His tag at the C-terminus. Sequence: Met 1-Arg 216 Fusion Tag: C-6His Accession: NP_031675.1 Species: Mouse Expressed Host: Human Cells Shipping Conditions: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 23.1 kDa Applied MM: 45-50 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH7.4. Reconstitution: Please refer to it for detailed information. Background: CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. Among dendritic cells (DC), CD48 is selectively expressed on circulating myeloid DC and resident bone marrow and thymus DC. CD2, 2B4, and heparan sulfate function as CD48 ligands. CD48 is competent to transduce signals and can also trigger signaling through CD2 or 2B4. CD48 expressed on NK cells is coactivating, whereas CD48 expressed on other cell types inhibits NK cell activation.