Recombinant Mouse Low affinity IgG Fc receptor III Protein
PKSM041224
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Supplier: Elabscience
Product Name: Recombinant Mouse Low affinity IgG Fc receptor III Protein
Catalog No. PKSM041224
Product Type: recombinant protein
Size: 50 ug
Activity: Measured by its binding ability in a functional ELISA.Immobilized mouse FCGR3-His at 10 ?g/ml (100 ?l/well) can bind biotinylated human IgG1The EC50 of biotinylated human IgG1 is 0.12-0.28 ?g/ml.
Protein Construction: Recombinant Mouse Low affinity IgG Fc receptor III is produced by our Mammalian expression system and the target gene encoding Ala31-Thr215 is expressed with a 6His tag at the C-terminus.
Sequence: Met 1-Thr 215
Fusion Tag: C-6His
Accession: P08508-1
Species: Mouse
Expressed Host: Human Cells
Shipping Conditions: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Purity: ?95% as determined by reducing SDS-PAGE.
Endotoxin: <1.0 EU per ?g as determined by LAL test.
Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7? for 2-7 days.
Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 22.0 kDa Applied MM: 35-40 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH7.4. Reconstitution: Please refer to it for detailed information. Background: Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains consisting of immunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a variety of myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligand binding. Fcgr3 is IgG binding and activation or inhibition of immune responses such as antibody-dependent cellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and positive regulation of type I/IIa/III hypersensitivity.
Reconstituted protein solution can be stored at 4-7? for 2-7 days.
Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 22.0 kDa Applied MM: 35-40 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH7.4. Reconstitution: Please refer to it for detailed information. Background: Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains consisting of immunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a variety of myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligand binding. Fcgr3 is IgG binding and activation or inhibition of immune responses such as antibody-dependent cellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and positive regulation of type I/IIa/III hypersensitivity.
