Recombinant Mouse Serum Amyloid P Component Protein

Supplier: Elabscience Product Name: Recombinant Mouse Serum Amyloid P Component Protein Catalog No. PKSM041239 Product Type: recombinant protein Size: 50 ug Activity: 1. Measured by its binding ability in a functional ELISA. Immobilized mouse APCS at 10 ?g/ml (100 ?l/well) can bind biotinylated human Fibronectin Fragment 2 with a linear ranger of 0.625-5 ?g/ml.2. Measured by its ability to bind mouse CD64-AVI in a functional ELISA. Protein Construction: Recombinant Mouse Serum Amyloid P Component is produced by our Mammalian expression system and the target gene encoding Gln21-Asp224 is expressed with a 6His tag at the C-terminus. Sequence: Met 1-Glu 224 Fusion Tag: C-6His Accession: NP_035448.2 Species: Mouse Expressed Host: Human Cells Shipping Conditions: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 24.9 kDa Applied MM: 28-32 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS, pH7.4. Reconstitution: Please refer to it for detailed information. Background: Pentraxin 2 (PTX2), also known as Serum amyloid P (SAP), is a highly conserved, naturally circulating plasma protein and a soluble pattern recognition receptor of the innate immune system. The unique binding activities indicated that it may play an important role in the removal of damaged tissue. PTX2 belongs to the pentraxin family, is universally present in amyloid deposits. Mouse with targeted deletion of the PTX2 gene shows retarded and reduced induction of experimental reactive systemic (AA type) amyloidosis confirmed that it does indeed contribute to pathogenesis of amyloidosis and is a valid therapeutic target. In recent discovery, PTX2 can be used as a powerful antifibrotic agent to regulate certain monocyte differentiation states.