Mouse Monoclonal Antibody to ZAP70

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 3D2A4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ZAP70 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 70kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=89
Reference: 1. Sigal Gelkop , Gerrald D. Gish, Yael Babichev J Immunol. 2005 Dec 15;175(12):8123-32. ; 2. Joaquim Carreras , Neus Villamor ,Lluis Colomo J Pathol. 2005 Mar;205(4):507-13. ; 3. Claire Hivroz Med Sci (Paris). 2005 Feb;21(2):150-5. ;

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