Mouse Monoclonal Antibody to SYK

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 8C1A3;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of SYK (aa296-484) expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: N/A
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=215
Reference: 1. Blood. 2006 Nov 15;108(10):3352-9 ; 2. Int J Mol Med. 2006 Oct;18(4):547-57. ; 3. J Exp Med. 2006 Dec 25;203(13):2829-40.

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