Mouse Monoclonal Antibody to RICTOR

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, G?L and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, G?L, Sin1 and rictor . The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes . This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Monkey; Mouse
Clone: 4H5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human RICTOR expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 192kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=492
Reference: 1. Genes Dev. 2006 Oct 15;20(20):2820-32. ; 2. Biochem Biophys Res Commun. 2008 Aug 8;372(4):578-83.

Note: Highly recommend to send quote request for product availability and estimated shipping charge