Mouse Monoclonal Antibody to BLK

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development . Activation of B cells by various ligands is accompanied by activation of Blk . It has been suggested that Blk is involved in the control of B cell differentiation and proliferation . Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis . Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response .
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1E6;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human BLK expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 58kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=534
Reference: 1. N Engl J Med. 2008 Feb 28;358(9):900-9. ; 2. Genes Immun. 2009 Apr;10(3):219-26. ; 3. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14460-5.

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