Mouse Monoclonal Antibody to DLK1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 3A10;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human DLK1 expressed in E. Coli. ;
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 41kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=679
Reference: 1. Epigenetics. 2009 Oct 1;4(7):469-75. ; 2. Mol Biol Cell. 2009 Jul;20(14):3353-62.  ;

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