Mouse Monoclonal Antibody to SFTPC

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified. ; ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5E6A9;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human SFTPC (AA: 60-180 ) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 21kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=840
Reference: 1.Am J Respir Cell Mol Biol. 2011 Sep;45(3):498-509. ; 2.J Biol Chem. 2009 Nov 27;284(48):33377-83. ;

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