Mouse Monoclonal Antibody to CHRNA2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: N/A; IHC: N/A
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7G12D10
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CHRNA2 (AA: extra 27-264) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 60kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4418
Reference: 1.Hum Genet. 2014 May;133(5):575-86. 2.Epilepsia. 2015 May;56(5):e53-7.

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